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Sharma, Nisha
- Sodium Bicarbonate Aqueous Matrix as Novel Industrial Solvent for Benzoylation of Some Ar-OH, Ar-NH and R-HN Functionalities
Abstract Views :277 |
PDF Views:82
Authors
Affiliations
1 University Institute of Pharmacy, CSJM University, Kanpur 208 024, IN
1 University Institute of Pharmacy, CSJM University, Kanpur 208 024, IN
Source
Current Science, Vol 113, No 10 (2017), Pagination: 1832-1834Abstract
It is a well accepted fact that chemical transformations can occur in solid, liquid and gaseous matrix; however, liquid matrix (solvent) dominates due to certain distinct multi-dimensional advantages especially at molecular level, making it a versatile tool for industrial manufacturing processes. It has been estimated that 28-million metric tonnes (MMT) of organic solvents are commercialized globally for different industrial purposes, majority of which get utilized in chemical and pharmaceutical manufacturing.References
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- Chowrasia, D., Synthetic Paradigm, 2016, 8–9.
- Greene, T. W., Protective Groups in Organic Synthesis, Wiley, NY, USA, 1981, pp. 261–263.
- Reese, C. B., Protective Groups in Organic Chemistry, Plenum Press, London, UK, 1973, pp. 52–53.
- Ando, W. and Tsumaki, H., Synth. Commun., 1983, 13, 1053–1056.
- Taylor, E. C., Mclay, G. W. and McKillop, A., J. Am. Chem. Soc., 1968, 90(1), 2422–2423.
- Illi, V. O., Tetrahedron Lett., 1979, 20, 2431–2432.
- Vogel, A. I., Practical Organic Chemistry, Longman Group Limited, London, UK, 1956, pp. 582–583.
- Mann, F. G. and Saunders, B. S., Practical Organic Chemistry, Longman Group Limited, London, 1978, pp. 243–244.
- Paul, S., Nanda, P. and Gupta, R., Molecules, 2003, 8, 374–380.
- Antiproliferative and Antibacterial Activity of Some Para-Substituted Benzylideneacetophenones and Establishing their Structure Activity Relationship
Abstract Views :275 |
PDF Views:81
Authors
Deepak Chowrasia
1,
Nisha Sharma
1,
Ajay Kumar
1,
Vinod Dohrey
1,
Md. Arshad
2,
Asif Jafri
2,
Juhi Rais
2,
Madhu Gupta
2,
Sahabjada
2
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
1 University Institute of Pharmacy, Chhatrapati Shahu Ji Maharaj University, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
Source
Current Science, Vol 114, No 02 (2018), Pagination: 391-396Abstract
We report here in-vitro antiproliferative and antibacterial activity of para-substituted benzylideneacetophenones and established their structure activity relationship to optimize para position as a biologically-oriented-synthetic target for design of small moleculebased future anticancer/antibacterial agents. Among synthesized compounds, 1c exhibits excellent antiproliferative activity against human osteosarcoma cell line (MG-63) compared to 1b and 1a suggesting dimethylamino (–N(CH3)2) functionality as a better para-substituted analogue for in-future anticancer agents. Similarly antibacterial screening of the aforesaid compounds against different strains of Gramnegative and Gram-positive bacteria reveals methoxy (–OCH3) rather than dimethylamino (–N(CH3)2) as a better para-substituted functionality on ring B comparatively. From our results, we justify our theory ‘lipophilicity affects antibacterial activity’.Keywords
Antiproliferative, Antibacterial Assay, Benzylideneacetophenone, MTT Assay.References
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- http://www.worldheartfoundation.org/fileadmin/user_upload/documents/advocacy/resources/articles_series_report/WEF_havard_HE_globaleconomicburdennoncommunicabledisease_2011.pdf
- Chowrasia, D., Karthikeyan, C., Choure L., Sahabjada, Gupta, G. and Arshad, M., Synthesis, characterization and anti cancer activity of some fluorinated 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. Arab. J. Chem., 2013 (in press).
- Chowrasia, D., Sharma, N., Chaurasia, A., Bharti, A. and Pratap, A., Chalcone as a principle pharmacophore for design and development of novel anticancer agents. Pharmacophore, 2016, 7(5), 35–42.
- Chowrasia, D., Sharma, N. and Arshad, M., In vitro antiproliferative activity of M. Azedarach; Pharma. Tut. Magz., 2017, 5(02), 46–49.
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- Mijovie, G., Andric, B., Terzic, D., Lopicic, M. and Dupanovic, B., Antibiotic susceptibility of Salmonella spp.: a comparison of two surveys with a 5 years interval. J. IMAB – Annu. Proc., (Scientific Papers). 2012, 18(1), 216–219.
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- Wu, J. Z., Cheng, C. C., Shen, L. L., Wang, Z. K., Wu, S. B. and Li, W. L., Synthetic chalcones with potent antioxidant ability on H2O2-induced apoptosis in PC12 cells. Int. J. Mol. Sci., 2014, 15(10), 18525–18539.
- Kumar, C. S. C., Loh, W. S., Ooi, C. W., Quah, C. K. and Fun, H. K., Heteroarylchalcones: design, synthesis, X-ray crystal structures and biological evaluation. Molecules, 2013, 18(10), 12707–12724.
- Nguyen, T. T. N., Do, T. H., Huynh, T. N. P., Tran, C. D. T. and Thai, K. M., Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics. Molecules, 2012, 17(6), 6684–6696.
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- Kang, J. E., Cho, J. K., Curtis-Long, M. J., Ryu, H. W., Kim, J. H. and Kim, H. J., Preparation of substituted pyridines and pyridazines with angiogenesis inhibiting activity for pharmaceutical use as antitumor agents. Molecules, 2013, 140–153.
- Solomon, V. R. and Lee, H., Anti-breast cancer activity of heteroarylchalcone derivatives. Biomed. Pharmacother., 2012, 66(3), 213–220.
- Kumar, D., Kumar, N. M., Akamatsu, K., Kusaka, E., Harada, H. and Ito, T., Synthesis and biological evaluation of indolylchalcones as antitumor agents. Bioorg. Med. Chem. Lett., 2010, 20(13), 3916–3919.
- Domyngueza, J. N., Charris, J. E., Loboa, G., De Domýnguezb, N. G., Moreno, M. M. and Riggione, F., Synthesis of quinolinylchalcones and evaluation of their antimalarial activity. Eur. J. Med. Chem., 2001, 36(6), 555–560.
- Hayat, F., Moseley, E., Salahuddin, A., Zyl, R. L. V. and Azam, A., Antiprotozoal activity of chloro-quinoline based chalcones. Eur. J. Med. Chem., 2011, 46(5), 1897–1905.
- Kotra, V., Ganapathy, S. and Adapa, S. R., Synthesis of new quinolinylchalcones as anticancer and anti-inflammatory agents. Indian J. Chem., 2010, 49(B), 1109–1116.
- Rizvi, S. U. F., Siddiqui, H. L., Johns, M., Detorio, M. and Schinazi, R. F., Anti-HIV-1 and cytotoxicity studies of piperidylthienylchalcones and their 2-pyrazoline derivatives. Med. Chem. Res., 2012, 21(11), 3741–3749.
- Ahmad, M. S., Sahabjada, Jafri, A., Ahmad, S., Afzal, M. and Arshad, M., Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cyle arrest. PLoS ONE, 2014, 9(10), e110003; doi:10.1371/journal.pone.0098409.
- Kaleem, S., Siddiqui, S., Hussain, A., Arshad, M., Akhtar, J., Rizvi, A. and Siddiqui, H. H., Eupalitin induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase3 activity. Cell Biol. Intern., 2016, 40(2), 196–203.
- Thiamine an Unexplored, Ecologically Hormonizable, Nontoxic Catalyst for Benzoylation
Abstract Views :226 |
PDF Views:77
Authors
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj University, Kalyanpur, Kanpur 208 024, IN
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj University, Kalyanpur, Kanpur 208 024, IN
Source
Current Science, Vol 115, No 11 (2018), Pagination: 2130-2133Abstract
Numerous catalysts have been evaluated to assist benzoylation since its origin (1883), each having their own pros and cons with respect to synthetic environment. However, the one (thiamine) we report here is superior as well as multidimensionally advantageous with reference to non-hygroscopic characteristic, stability at room temperature and reaction conditions, uninflammable, non-volatile, easy to handle, non-corrosive, environmentally harmonizable, biodegradable, recyclable and non-toxic. Our result denies the traditional concept of ‘Inorganic alkaline assistance’ for benzoylation. The percentage yield of benzoylated product obtained by thiamine assisted method was found to be comparable with traditional methods. Furthermore non-catalyst assisted benzoylation in neat water was also studied and the results coincide with traditional as well as thiamine-assisted method reported here with some limitations.Keywords
Benzoylation, Catalyst, Clean Water, Thiamine.References
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- Mann, F. G. and Saunders, B. S., Practical Organic Chemistry, Longman Group Ltd, London, UK, 1978, pp. 243–244.
- Carey, F. A. and Hodgson, K. O., Efficient syntheses of methyl 2-O-benzoyl-4,6-O-benzylidene-α-D-glucopyranoside and methyl 2-O-benzoyl-4,6-O-benzylidene-α-D-ribo-hexopyranosid-3-ulose. Carbohydrate Res., 1970, 12(3), 463–465.
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- Illi, V. O., Tetrahedron Lett., 1979, 20, 2431–2432.
- Chowrasia, D. and Sharma, N., Solvent substitution evaluation of limestone water as a medium for benzoylation. Arch. Chem. Res., 2016, 1, 1.
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- Synthetic Modulation Including Structure Establishment, Antiproliferative Activity of Some p-Aryl Substituted (Z)-2-Cyanoethylideneacetohydrazides, and their Structure Activity Relationship
Abstract Views :236 |
PDF Views:85
Authors
Deepak Chowrasia
1,
Nisha Sharma
1,
Ajay Kumar
1,
Md Arshad
2,
Sahabjada Siddiqui
2,
Asif Jafri
2,
Juhi Rahis
2
Affiliations
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj (CSJM) University, Kalyanpur, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
1 University Institute of Pharmacy, Chhatrapati Shahu ji Maharaj (CSJM) University, Kalyanpur, Kanpur 208 024, IN
2 Department of Zoology, Lucknow University, Lucknow 226 007, IN
Source
Current Science, Vol 115, No 12 (2018), Pagination: 2287-2290Abstract
A series of p-substituted aryl-2-cyanoethylideneacetohydrazides derivatives (2a-j) were successfully synthesized in the laboratory (yield 60–80%). The synthesized compounds were screened for their antiproliferative activity against MCF-7 (estrogen dependent human breast cancer cell line), SaOS-2 (osteosarcoma cell line), and K562 (myeloid leukemia cell line) by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) reduction assay. They showed moderate to mild antiproliferative activity, (2j) being the most potent in the series with an IC50 55, 64 and 35 μM against MCF-7, SaOS-2 and K562 cell lines, depict p-nitro as a better antiproliferative substituent comparatively. We have also tested the hypothesis – ‘Electron withdrawing phenomenon affects antiproliferative activity’.Keywords
Cancer, Cyanoacetohydrazide, Electron Withdrawing Ring Substituent, MTT Assay.References
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- Screening and Molecular Identification of Hypercellulase and Xylanase-Producing Microorganisms for Bioethanol Production
Abstract Views :218 |
PDF Views:87
Authors
Affiliations
1 Microbiology Laboratory, Department of Basic Sciences, Dr Y. S. Parmar University of Horticulture and Forestry, Nauni–Solan 173 230, IN
1 Microbiology Laboratory, Department of Basic Sciences, Dr Y. S. Parmar University of Horticulture and Forestry, Nauni–Solan 173 230, IN
Source
Current Science, Vol 120, No 5 (2021), Pagination: 841-849Abstract
The present study projects the baseline work for bioconversion of pine needles to second generation biofuel, which deals mainly with screening, molecular identification and optimization of process parameters for cellulase and xylanase production. In total, 89 hydrolytic enzymes producing isolates were isolated from the soils and ten potential enzyme producers (seven for cellulase and three for xylanase) were subjected to secondary screening by inducing physical and chemical mutation. The wild and mutant strains of hypercellulase producers N12 and Kd1 were identified as Bacillus stratosphericus N12 and Bacillus altitudinis Kd1 using 16S rRNA technique. The fungal isolates RF1 and F2 were identified on the basis of 5.8 rRNA ITS technique and identified as Rhizopus oryzae, RF1 and Rhizopus delemar, F2 respectively. The mutant strains B. stratosphericus N12 (M) and B. altitudinis Kd1 (M) are highly stable till 10 generations. Cellulase activity increased from 3.230 to 5.983 IU, i.e. 85.23% increase in cellulase activity was achieved. Xylanase production increased from 51.32 to 95.25 IU with 85.60% increase in production. Solid-state fermentation was also performed by potential fungal strains, i.e. R. delemar F2 and R. oryzae RF1 using pine needles as the substrate.Keywords
Bioethanol, Cellulase, Solid-state Fermentation, Submerged Fermentation, Xylanase.References
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